Mol Metab. Richards BJ. United States: Truth in Wellness Books; The role of leptin in the control of insulin-glucose axis. Front Neurosci. Obesity Silver Spring. The effect of fiber on satiety and food intake: a systematic review. J Am Coll Nutr. Pan W, Kastin AJ. Leptin: a biomarker for sleep disorders? Sleep Med Rev. Dietary intakes and leptin concentrations.
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People who are obese are shown to have much higher levels of this hormone than individuals of average weight 4. It would seem that higher levels would be favorable, as there would be plenty available to communicate to your brain that your body is full and cease eating.
As a result, you continue to eat 5. Leptin resistance not only contributes to eating more but also signals your brain that you need to save energy, which leads you to burn calories at a slower rate 6.
In terms of weight loss, more leptin is not necessarily what matters. How well your brain interprets its signal is much more significant. Therefore, taking a supplement that increases blood leptin levels does not necessarily lead to weight loss. Some feature ingredients like alpha-lipoic acid and fish oil, while others contain green tea extract, soluble fiber or conjugated linoleic acid.
There are many studies involving weight loss supplements, but the effect of these supplements on improving leptin resistance and appetite remains unclear 8 , 9 , 10 , Some research has looked at African mango, or Irvingia gabonensis, and its proposed positive effect on leptin sensitivity and weight loss.
It has been shown to decrease leptin levels, which may be favorable for improving sensitivity 12 , In addition, some studies have observed that African mango produced a modest reduction in weight and waist circumference.
Note that research is limited to only a few, small studies 14 , Ultimately, further research is needed to conclude if supplements can influence leptin resistance. Leptin supplements contain various nutrients that are said to improve leptin sensitivity and promote fullness, but research is lacking. African mango may help lower levels of the hormone and improve sensitivity, but more studies are needed.
Usually, a pediatrician will order a blood test, and that will flag if a leptin deficiency is the issue. But again, she stresses, this is rare. Leptin, unfortunately, falls into that category. For starters, your body can't even absorb it in supplement form unless you have a legit deficiency, says Peter LePort, M. Leptin levels change in your body in response to food—which is why LePort recommends eating slowly and choosing foods that will fill you up to increase your feelings of satiety when you eat.
Some researchers are studying different tactics on mice and rats, but nothing has been found to work at this time, Stanford says. The bottom line: Take a hard pass on leptin supplements, and talk to your doctor if you have concerns about your weight.
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